Mr. Jackson
@mrjackson

HUMAN AMYLOID IMAGING CONFERENCE

The 18th edition of the HAI will be held in San Juan, Puerto Rico on January 12-14, 2026.

2026 PRELIMINARY PROGRAM

The event will be held at the Puerto Rico Convention Center in San Juan – poster details will be published later this week.

MONDAY, JANUARY 12, 2026

SESSION/PRESENTATION
PRESENTER/CHAIRS
08:00 am - 08:30 am
Check-in and Breakfast
Check-in and Breakfast
08:30 am - 08:45 am
Welcome Notes
Keith Johnson, Massachusetts General Hospital, Boston, MA, USA
08:45 am - 08:55 am
Alzheimer's Association Note
Maria Carrillo, Alzheimer’s Association, Chicago, IL, USA
08:55 am - 10:25 am
SESSION I: Amyloid-beta pathology: PET imaging
CHAIRS:
Keith Johnson, Massachusetts General Hospital, Boston, MA, USA
Christopher Rowe, Austin Health, Melbourne, Australia
08:55 am - 09:00 am
Session Overview
Chairs
09:00 am – 09:15 am
Auto-rADiology: Toward automated and explainable amyloid-PET interpretation using deep learning
Yu Xiao, Lund University, Lund, Sweden
09:15 am – 09:30 am
Choroidal-ventricular remodeling is associated with amyloid aggregation in Alzheimer’s disease
Brandon Hall, McGill University, Montréal, QC, Canada
09:30 am – 09:45 am
Updated evaluation of the baseline distribution of amyloid positivity and cognitive impairment among adults with Down syndrome in the ABC-DS project
Max McLachlan, University of Wisconsin-Madison, , Madison, WI, USA
09:45 am – 10:00 am
Heterogeneous patterns of off target signal with [18F]flutafuranol PET in ADNI4
Renaud La Joie, University of California, San Francisco, San Francisco, CA, USA
10:00 am - 10:25 am
Discussion
Discussion
10:25 am - 10:30 am
Blitz Session 1A
Blitz Session 1A
10:30 am - 11:30 am
Break/Poster Session 1A
Break/Poster Session 1A
11:30 am - 01:00 pm
SESSION II: Tau pathology: In vivo and postmortem measurements
CHAIRS:
Bradley Christian, University of Wisconsin-Madison, Madison, WI, USA
Melissa Murray, Mayo Clinic, Jacksonville, FL, USA
11:30 am - 11:35 am
Session Overview
Chairs
11:35 am – 11:50 am
The effects of 18F-MK-6240 PET extracerebellar off-target signal on the cerebellum and its substructures
Charles Chen, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA
11:50 am – 12:05 pm
Examining spatial relationships between ex-vivo flortaucipir retention and TMEM106b protein expression in a subset of neuropathologically confirmed frontotemporal lobar degeneration cases with TAR DNA-binding protein 43 pathology
Rodolpho Gatto, Mayo Clinic, Rochester, MN, USA
12:05 pm – 12:20 pm
Hypometabolism and atrophy patterns associated with advanced primary age-related tauopathy mimicking early-stage AD
Jesus Silva-Rodriguez, CIEN Foundation, Madrid, Spain
12:20 pm – 12:35 pm
Differential age- and Aβ-related tau-PET patterns between [18F]FTP and [18F]MK6240
Cecile Tissot, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
12:35 pm - 01:00 pm
Discussion
Discussion
01:00 pm - 02:00 pm
Lunch
Lunch
02:00 pm - 02:30 pm
Keynote: The neuropathological basis of current AD biomarkers: Sensitivity and pathogenetic implications
Dietmar Thal, KU Leuven, Leuven, Belgium
02:30 pm - 02:45 pm
Keynote Discussion
Keynote Discussion
02:45 pm - 04:15 pm
SESSION III: Alzheimer's disease biological staging and applications
CHAIRS:
Tobey Betthauser, University of Wisconsin-Madison, Madison, WI, USA
Thomas Karikari, University of Pittsburgh, Pittsburgh, PA, USA
02:45 pm - 02:50 pm
Session Overview
Chairs
02:50 pm – 03:05 pm
Combining quantitative and visual read approaches to tau-PET positivity and staging: The Tau-PET Working Group
Gil Rabinovici, University of California San Francisco, San Francisco, CA, USA
03:05 pm – 03:20 pm
Association between PET-based Alzheimer’s disease biological stage and autopsy findings
Derek Johnson, Mayo Clinic, Rochester, MN, USA
03:20 pm – 03:35 pm
Associations among plasma p-tau217, amyloid PET, tau PET, and cognitive testing in the screening cohort for the AHEAD 3-45 Study
Reisa Sperling, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
03:35 pm – 03:50 pm
Genetic predictors of multimodal brain tau pathology in older adults
Ting-Chen Wang, Vanderbilt University Medical Center, Nashville, TN, USA
03:50 pm - 04:15 pm
Discussion
Discussion
04:15 pm - 04:20 pm
Blitz Session 1B
Blitz Session 1B
04:20 pm - 05:20 pm
Break/Poster Session 1B
Break/Poster Session 1B
05:20 pm - 05:25 pm
The PET-tle Royale (HAI's very own synaptic showdown quiz)
Christopher Schwarz, Mayo Clinic, Rochester, MN, USA
05:30 pm - 07:30 pm
Networking Reception
Networking Reception

TUESDAY, JANUARY 13, 2026

SESSION/PRESENTATION
PRESENTER/CHAIR
08:00 am - 08:30 am
Check-in/Breakfast
Check-in/Breakfast
08:00 am - 08:30 am
Mentoring Session
Mentoring Session
08:30 am - 09:45 am
ISTAART Collaborations
CHAIR
09:45 am - 09:50 am
Blitz Session 2A
Blitz Session 2A
09:50 am - 10:50 am
Break/Poster Session 2A
Break/Poster Session 2A
10:50 am - 12:20 pm
SESSION IV: Longitudinal biomarker measurements of tau pathology
CHAIRS:
William Jagust, University of California, Berkeley, Berkeley, CA, USA
Heidi Jacobs, Massachusetts General Hospital, Boston, MA, USA
10:50 am - 10:55 am
Session Overview
Chairs
10:55 am – 11:10 am
Preliminary comparative longitudinal performance of Flortaucipir and MK6240: rates of change, effect sizes, and power estimates in the HEAD Study
Guilherme Bauer-Negrini, University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA
11:10 am – 11:25 am
Standardized expression of longitudinal tau accumulation using the CenTauR scale
Brian Lopresti, University of Pittsburgh, Pittsburgh, PA, USA
11:25 am – 11:40 am
TauPace as a novel, time-based metric to investigate accelerated tau and clinical progression in preclinical AD
William Coath, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
11:40 am – 11:55 am
Proteomic signatures track tau spread in Alzheimer’s disease
Arthur Macedo, McGill University, Montreal, QC, Canada
11:55 am - 12:20 pm
Discussion
Discussion
12:20 pm - 01:20 pm
Lunch
Lunch
01:20 pm - 01:50 pm
Keynote: The role of AI in neuroimaging for Alzheimer’s disease diagnosis, staging, and prognosis
Joyita Dutta, University of Massachusetts, Amherst, MA, USA
01:50 pm - 02:05 pm
Keynote Discussion
Keynote Discussion
02:05 pm - 03:35 pm
SESSION V: Alpha-synuclein in PD and MSA: PET imaging
CHAIRS:
Jamie Eberling, Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA
Robert Mach, University of Pennsylvania, Philadelphia, PA, USA
02:05 pm - 02:10 pm
Session Overview
Chairs
02:10 pm – 02:25 pm
Preclinical and early clinical assessment of [11C]MODAG-005, a novel PET tracer for imaging alpha-synuclein aggregates
Ann-Kathrin Grotegerd, University Tuebingen, Tuebingen, Germany
02:25 pm – 02:40 pm
Clinical evaluation of [11C]MK-7337: insights into the distribution of a-synuclein pathology in Parkinson’s disease
Eric Hostetler, Merck & Co., Inc., West Point, PA, USA
02:40 pm – 02:55 pm
[11C]M503-1619 alpha synuclein PET imaging in Parkinson’s disease and multiple system atrophy
Chia-Ju Hsieh, University of Pennsylvania, Philadelphia, PA, USA
02:55 pm – 03:10 pm
Quantitative analysis of human ¹⁸F-FD4 α-synuclein PET imaging data in Parkinson’s Disease and Multiple System Atrophy subtypes
Roger Gunn, XingImaging, London, UK
03:10 pm - 03:35 pm
Discussion
Discussion
03:35 pm - 03:40 pm
Blitz Session 2B
Blitz Session 2B
03:40 pm - 04:40 pm
Break/Poster Session 2B
Break/Poster Session 2B
04:40 pm - 06:10 pm
SESSION VI: Neuroinflammation
CHAIRS:
Chuck Kreisl, Eisai, Washington DC, USA
David Morgan, Michigan State University, Grand Rapids, MI, USA
04:40 pm - 04:45 pm
Session Overview
Chairs
04:45 pm – 05:00 pm
Deep mass spectrometry-based plasma proteomics reveals signatures of reactive astrocytes in Alzheimer's disease
Ruyu Shi, University of Pittsburgh, Pittsburgh, PA, USA
05:00 pm – 05:15 pm
Microglia-Astrocyte interplay modulates tau phosphorylation in Alzheimer's disease
Tevy Chan, McGill University , Montreal, QC, Canada
05:15 pm – 05:30 pm
Astrogliosis mediates the effects of amyloid, moderated by CVD, on tau and cognition in non-demented individuals
Victor Villemagne, University of Pittsburgh, Pittsburgh, PA, USA
05:30 pm – 05:45 pm
TSPO expression patterns in the postmortem brain: relevance to neuroinflammation imaging
Christina Moloney, Mayo Clinic, Rochester, MN, USA
05:45 pm - 06:10 pm
Session Discussion
Session Discussion
06:10 pm - 06:15 pm
The PET-tle Royale (HAI's Re-Myelination Showdown Quiz)
Christopher Schwarz, Mayo Clinic, Rochester, MN, USA

WEDNESDAY, JANUARY 14, 2026

 

SESSION/PRESENTATION
PRESENTER/CHAIR
08:00 am - 09:00 am
Check-in/Breakfast
Check-in/Breakfast
08:15 am - 08:45 am
Mentoring Session
Mentoring Session
09:00 am - 10:20 am
SESSION VII: Early and intermediate signals and prognostic value
CHAIRS:
Sterling Johnson, University of Wisconsin-Madison, Madison, WI, USA
Sylvia Villeneuve, McGill University, Montreal, QC, Canada
09:00 am - 09:05 am
Session Overview
Chairs
09:05 am – 09:20 am
Discordance between amyloid PET visual read and quantitation: false positives or early pathology detection?
Margo Heston, University of California, San Francisco, San Francisco, CA, USA
09:20 am – 09:35 am
Considerations for repeat testing of amyloid PET-validated plasma pTau217 diagnostic assays in the screening cohort for the AHEAD 3-45 study
Robert Rissman, Keck School of Medicine of the University of Southern California, San Diego, CA, USA
09:35 am – 09:50 am
The prognostic value of p tau217 levels on progression to clinical impairment over 2, 5 and 10 years
Rachel Buckley, Massachusetts General Hospital, Boston, MA, USA
09:50 am - 10:05 am
Distribution of tau and amyloid pathology across cognitive states in a population-based, admixed autopsy cohort
Lea Grinberg, Mayo Clinic, Jacksonville, FL, USA
10:05 am - 10:30 am
Session Discussion
Session Discussion
10:30 am - 10:35 am
Blitz Session 3A
Blitz Session 3A
10:35 am - 11:35 am
Break/Poster Session 3A
Break/Poster Session 3A
11:35 am - 12:05 am
Keynote: Integrated proteomics for target and biomarker discovery in Alzheimer’s disease
Nick Seyfried, Emory University, Atlanta, GA, USA
12:05 pm - 12:20 pm
Keynote Discussion
Keynote Discussion
12:20 pm - 01:10 pm
Lunch
Lunch
01:10 pm - 02:40 pm
SESSION VIII: Moderators and co-pathologies
CHAIRS:
Annie Cohen, University of Pittsburgh, Pittsburgh, PA, USA
Trey Hedden, Icahn School of Medicine at Mount Sinai, New York, NY, USA
01:10 pm - 01:15 pm
Session Overview
Chairs
01:15 pm – 01:30 pm
Investigating the role of socioeconomic status on AD biomarker relationships
Nazanin Ovaici, University of California, Berkeley, Berkeley, CA, USA
01:30 pm – 01:45 pm
Blood LDL cholesterol synergistically amplifies tau pathology and cognitive outcome in an APOE4-dependent manner
Tina Wang, Eli Lilly and Company, Indianapolis, IN, USA
01:45 pm – 02:00 pm
Mismatch between tau burden and cognitive domain performance identifies sub-groups with specific co-pathologies
Christopher Brown, University of Pennsylvania, Philadelphia, PA, USA
02:00 pm – 02:15 pm
Characterizing the brain-wide atrophy pattern of LATE-NC-associated hippocampal sclerosis: an imaging-pathologic association study
Michel Grothe, Reina Sofia Alzheimer Center, CIEN Foundation, Madrid, Spain
02:15 pm - 02:40 pm
Session Discussion
Session Discussion
02:40 pm - 02:45 pm
Blitz Session 3B
Blitz Session 3B
02:45 pm - 03:45 pm
Break/Poster Session 3B
Break/Poster Session 3B
03:45 pm - 05:20 pm
SESSION IX: Therapeutics: Anti-abeta and anti-tau effects
CHAIRS:
Suzanne Schindler, Washington University at St Louis, MO, USA
Christopher Van Dyck, Yale School of Medicine, New Haven, CT, USA
03:45 pm - 03:50 pm
Session Overview
Chairs
03:50 pm – 04:05 pm
Tau pathology interferes with amyloid removal by gantenerumab
Matteo Tonietto, Hoffmann-La Roche, Basel, Switzerland
04:05 pm – 04:20 pm
Clinical and PET outcomes following Aβ-targeting therapies in sporadic early-onset Alzheimer’s disease: Trial emulation using the LEADS cohort
Konstantinos Chiotis, University of California San Francisco, San Francisco, CA, USA
04:20 pm – 04:35 pm
Tau positron emission tomography data from the open-label extension study of TOGETHER: a double-blind, placebo-controlled Phase II study of bepranemab in prodromal–mild Alzheimer’s disease (AD)
Joël Mercier, UCB, Braine-l’Alleud, Belgium
04:35 pm – 04:50 pm
Cortical laminar and Aβ species-specific correspondence between antemortem Aβ-PET and postmortem pathology in aducanumab-treated Alzheimer’s disease
Baayla Boon, Mayo Clinic, Jacksonville, FL, USA
04:50 pm – 05:05 pm
In vivo and post-mortem evidence of downstream pathophysiologic effects of treatment-related amyloid clearance
David Wolk, University of Pennsylvania, Philadelphia, PA, USA
05:05 pm - 05:30 pm
Session Discussion
Session Discussion
05:30 pm - 05:40 pm
Awards Ceremony
HAI Executive Committee
05:40 pm - 05:45 pm
Concluding Remarks
Keith Johnson, Massachusetts General Hospital, Boston, MA, USA

2026 GUEST LECTURES


JOYITA DUTTA, PhD – UNIVERSITY OF MASSACHUSETTS AMHERST

Dr. Joyita Dutta is a Professor with tenure in the Department of Biomedical Engineering at the University of Massachusetts Amherst. She received her BTech (Honors) from the Indian Institute of Technology Kharagpur and MS and PhD from the University of Southern California. She directs the Biomedical Imaging and Data Science Laboratory (BIDSLab) at UMass Amherst, which develops signal processing and artificial intelligence (AI) techniques for image, graph, and time-series datasets. Her scientific contributions include the development of a broad range of tools for medical image enhancement and reconstruction with a focus on multimodality information integration. Her current research interests include developing AI approaches for the diagnosis and prognosis of Alzheimer’s disease.

Dr. Dutta was the recipient of the 2016 SNMMI Tracy Lynn Faber Memorial Award and the 2016 IEEE Bruce Hasegawa Young Investigator Medical Imaging Science Award. Dr. Dutta has served as a member of the SNMMI AI Task Force and the Program Chair for the 2022 IEEE Medical Imaging Conference in Milan, Italy. She is the Immediate Past President of the SNMMI Physics, Instrumentation and Data Sciences Council.

Dr. Dutta will present: “The role of AI in neuroimaging for Alzheimer’s disease diagnosis, staging, and prognosis.”

 

NICHOLAS SEYFRIED, DPHIL – EMORY UNIVERSITY

Dr. Nick Seyfried is a Professor in the Departments of Biochemistry and Neurology at Emory University and Associate Director of the Emory Center for Neurodegenerative Disease. He has over 20 years of research experience and more than 230 publications in the field of neurodegenerative diseases, particularly Alzheimer’s disease (AD) and related dementias.

At Emory, Dr. Seyfried leads a team that applies proteomics and other multi-omic approaches to both fundamental and translational research. He
currently serves as MPI of NIH-funded research consortia, including the Parkinson’s Disease Biomarker Program (PDBP), which focuses on identifying novel protein biomarkers for Lewy body dementia, and the newly funded Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center Without Walls, which aims to discover therapeutic targets and biomarkers for cerebral amyloid angiopathy.

He serves as Director of the Biomarker Core for the NIH-funded Emory Goizueta Alzheimer’s Disease Research Center (ADRC), where he leads efforts to develop and validate new protein biomarkers in cerebrospinal fluid (CSF) and plasma.

As part of the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD), his team developed a high-throughput proteomic pipeline to analyze thousands of human postmortem brain tissues and biofluids. This work has enabled the classification of brain proteomes into biologically meaningful modules associated with specific brain cell types and clinicopathological phenotypes, with the goal of uncovering early mechanisms and biomarkers for AD.

Dr. Seyfried will present: “Integrated Proteomics for Target and Biomarker Discovery in Alzheimer’s Disease”.

DIETMAR THAL, MD, PhD – KU LEUVEN

Dr.Dietmar R. Thal, MD, PhD, is a neuropathologist and professor for Neuropathology at KU-Leuven (Belgium) with his main research focus on Alzheimer’s disease. His major interest is the expansion and maturation of protein aggregates in this disorder. He was able to discover phases describing the expansion of amyloid plaque pathology in the human brain. These phases are currently included in the diagnostic criteria for the neuropathological assessment of Alzheimer’s disease (known as “Thal” amyloid phases).

Prof. Thal could show that the current amyloid PET-methods are usually restricted to the detection of moderate – advanced phases of amyloid plaque pathology distribution and, in so doing, represent a valuable tool for diagnosing the symptomatic disease and advanced stages of preclinical AD but not for picking up very early stages of the disease.

In addition, his group was able to show that not only the anatomical expansion of amyloid plaque aggregates plays a role in the pathogenesis of Alzheimer’s disease but also the maturation of the aggregates, meaning that the composition of amyloid plaques, soluble and insoluble amyloid aggregates, and tau lesions changes over time with specific proteins becoming detectable only in the symptomatic cases. Recently, his group showed that tau and TDP-43 aggregates physically interact in AD and that this interaction increases local tau pathology and neuron death, presumably due to an activation of the necroptosis pathway.

Dr Thal will present: “The neuropathological basis of current AD biomarkers: Sensitivity and pathogenetic implications”